A new succinylcholine-based assay of plasma cholinesterase.

Shortened action of succinylcholine in individuals with cholinesterase C <Subscript>5 </Subscript> isozyme

To test the possibility that individuals with and without plasma cholinesterase Cs isozyme have differences in neuromuscular sensitivity to succinylcholine chloride, we ~ramined the effects of succinylcholine in these two groups of patients. Sera from 491 adult patients were examined for presence of the plasma cholinesterase Cs isozyme by use o f electrophoresis with polyacrylamide ; 24 were posi-

Plasma cholinesterase deficiency in a neonate.

We report a two-day-old infant who had a period of apnoea lasting six hours following the intravenous administration of succinylcholine (Sch). The results of her plasma cholinesterase level and dibucaine number indicate a congenital absence of plasma cholinesterase (PChE) enzyme, although both parents and siblings had normal cholinesterase levels and dibucaine numbers. This is believed to be th...

Increased plasma cholinesterase activity and succinylcholine resistance: a genetic variant.

Recovery of residual curarization after red blood cell transfusion

BACKGROUND The muscle-relaxing effects of succinylcholine are terminated via hydrolysis by plasma cholinesterase. There are multiple genetic variants of this enzyme and clinical circumstances that might influence the activity of plasma cholinesterase and eventually lead to prolonged neuromuscular blockade following succinylcholine application. CASE REPORT Here, we report a parturient woman wi...

RELATIONSHIP BETWEEN SUCCINYLCHOLINEINDUCED APNEA AND DIBUCAINE NUMBER IN PATIENTS WITH GENETIC DEFICIENCY OF PLASMA CHOLINESTERASE

In this study, a commercially available kit in which propionylthiocholine is used as a substrate and a dibucaine solution to determine the variants of the enzyme were utilized. Plasma cholinesterase activity of 151 patients who underwent different operations was measured during a period of six months. The mean±SD of the enzyme activity in 150 patients was 4.39±1.17 kU/L .. Seventeen patie...